Runes are also used in certain Horadric Cube recipes. For example, you can use the Ral rune along with damaged gear to D2R Items repair it. This is an excellent option in the event that you're lacking gold and can't afford repairs from a seller. Runes can be combined together using the Horadric Cube; this is commonly referred to as "cubing up" and it is a common way to reach the next level rune without needing to search for it in the wild. For example, if own three El runes but need one more, put the three El runes in the Cube and hit the transmute button. The result will be and out will pop an Eld rune. The upgrade recipe is listed in the rune chart to the left.
The quest for Hellforge found in Act 4 will always drop some runes, and it can be used to pay for a quick run through the acts. The Countess's room, in the lower part of the Forgotten Tower in Act 1's Black Marsh, is another great source of runes.Because the runes are a set limit of rarity, which ranges from most frequent (El) all the way to the rarest (Zod) typically, they're used as the economy in Diablo 2. El Through Lem are generally considered low runes. Pul up to Gul are generally regarded as mid runes and Vex to Zod are typically considered to be high runes. If you encounter middle or high runes while on your travels, make sure not to dispose of the runes easily!
Runewords are some of the most potent items you can create during Diablo 2: Resurrected, but they do require time to accomplish. First, you need to find the appropriate runes for the runeword. Next, you must find the corresponding weapon, shield, or armor which is able to take the runeword. The item must possess an exact number of sockets that allow the runeword to function, and the runes should be placed into the item that is socketed in the appropriate order. The item must also be simple (white) or magic (blue) or rare (yellow) unique (gold) or D2R ladder items buy set (green) items that have sufficient sockets won't work with runewords.